Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00KEF
|
||||
| Former ID |
DIB011416
|
||||
| Drug Name |
Org-2766
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] | Discontinued in Phase 3 | [544514] | ||
| Company |
Organon BioSciences
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C40H55N9O11S
|
||||
| Canonical SMILES |
S(=O)(=O)(CC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](<br />C(=O)N[C@@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)CCCCN)Cc1cccc<br />c1)Cc1nc[nH]c1)CCC(=O)O)N)C
|
||||
| CAS Number |
CAS 50913-82-1
|
||||
| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Tumor necrosis factor receptor superfamily member 16 | Target Info | Modulator | [526759] | |
| Pathway Interaction Database | p75(NTR)-mediated signaling | ||||
| Neurotrophic factor-mediated Trk receptor signaling | |||||
| Reactome | Axonal growth inhibition (RHOA activation) | ||||
| NRAGE signals death through JNK | |||||
| p75NTR negatively regulates cell cycle via SC1 | |||||
| Regulated proteolysis of p75NTR | |||||
| NADE modulates death signalling | |||||
| NRIF signals cell death from the nucleus | |||||
| p75NTR recruits signalling complexes | |||||
| NF-kB is activated and signals survival | |||||
| Axonal growth stimulation | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.