Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0H1HP
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| Former ID |
DIB002906
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| Drug Name |
RPR-109891
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| Synonyms |
Klerval; RPR-109039
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| Drug Type |
Small molecular drug
|
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| Indication | Angina pectoris [ICD9: 413; ICD10:I20] | Discontinued in Phase 2 | [546386] | ||
| Company |
Rhone-Poulenc SA
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| Structure |
|
Download2D MOL |
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| Formula |
C26H45N5O6
|
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| Canonical SMILES |
CCN(CC(=O)NC(CC(=O)O)C(=O)NC(CC1CCCCC1)C(=O)N)C(=O)CCCC<br />2CCNCC2
|
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| InChI |
1S/C26H45N5O6/c1-2-31(23(33)10-6-9-18-11-13-28-14-12-18)17-22(32)29-21(16-24(34)35)26(37)30-20(25(27)36)15-19-7-4-3-5-8-19/h18-21,28H,2-17H2,1H3,(H2,27,36)(H,29,32)(H,30,37)(H,34,35)/t20-,21-/m0/s1
|
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| InChIKey |
PWINFPFVCZSLBF-SFTDATJTSA-N
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| CAS Number |
CAS 205510-69-6
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Glycoprotein IIb/IIIa receptor | Target Info | Modulator | [525810] | |
| Reactome | Platelet degranulation | ||||
| Elastic fibre formation | |||||
| PECAM1 interactions | |||||
| Molecules associated with elastic fibres | |||||
| Integrin cell surface interactions | |||||
| Syndecan interactions | |||||
| ECM proteoglycans | |||||
| Integrin alphaIIb beta3 signaling | |||||
| GRB2:SOS provides linkage to MAPK signaling for Integrins | |||||
| p130Cas linkage to MAPK signaling for integrins | |||||
| VEGFA-VEGFR2 Pathway | |||||
| MAP2K and MAPK activation | |||||
| References | |||||
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