Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0M6YE
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| Former ID |
DNC003699
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| Drug Name |
SKF-106760
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| Drug Type |
Small molecular drug
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| Indication | Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] | Terminated | [545630] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C23H39N9O8S2
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| Canonical SMILES |
CC(=O)CNC1CSSC(C(NC(=O)C(NC(=O)CNC(=O)C(N(C1=O)C)CCCN=C<br />(N)N)CC(=O)O)C(=O)N)(C)C
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| InChI |
1S/C24H41N9O8S2/c1-12(34)9-29-14-11-42-43-24(2,3)18(19(25)38)32-20(39)13(8-17(36)37)31-16(35)10-30-21(40)15(33(4)22(14)41)6-5-7-28-23(26)27/h13-15,18,29H,5-11H2,1-4H3,(H2,25,38)(H,30,40)(H,31,35)(H,32,39)(H,36,37)(H4,26,27,28)/t13-,14-,15-,18-/m0/s1
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| InChIKey |
ADQVGEYLOUWALW-XSWJXKHESA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Glycoprotein IIb/IIIa receptor | Target Info | Modulator | [556264] | |
| Reactome | Platelet degranulation | ||||
| Elastic fibre formation | |||||
| PECAM1 interactions | |||||
| Molecules associated with elastic fibres | |||||
| Integrin cell surface interactions | |||||
| Syndecan interactions | |||||
| ECM proteoglycans | |||||
| Integrin alphaIIb beta3 signaling | |||||
| GRB2:SOS provides linkage to MAPK signaling for Integrins | |||||
| p130Cas linkage to MAPK signaling for integrins | |||||
| VEGFA-VEGFR2 Pathway | |||||
| MAP2K and MAPK activation | |||||
| References | |||||
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