TTD | Drug: D00XRI

Drug General Information
Drug ID	D00XRI
Former ID	DIB014283
Drug Name	TJN-220
Synonyms	O-Ethylfangchinoline; O-ethylfangchinoline, Tsumura; 7-O-ethylfangchinoline, Tsumura
Drug Type	Small molecular drug
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Terminated	[545256]
Company	Tsumura & Co
Structure		Download 2D MOL 3D MOL
Formula	C39H44N2O6
Canonical SMILES	c12c3[C@@H](N(CCc3cc(c2OCC)OC)C)Cc2cc(Oc3ccc(C[C@H]4c5c<br />c(O1)c(cc5CCN4C)OC)cc3)c(cc2)OC
CAS Number	CAS 118160-59-1
PubChem Compound ID	3081672
Target and Pathway
Target(s)	Calcitonin receptor	Target Info	Modulator	[533777]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	Osteoclast differentiation
NetPath Pathway	RANKL Signaling Pathway
Reactome	G alpha (s) signalling events
Reactome	Calcitonin-like ligand receptors
WikiPathways	GPCRs, Class B Secretin-like
	RANKL/RANK Signaling Pathway
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545256	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002586)
Ref 533777	Evaluation of the long-lasting antihypertensive action of 7-O-ethylfangchinoline. Jpn J Pharmacol. 1994 Sep;66(1):35-46.

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Drug Information