Drug Information

Drug General Information
Drug ID
D03EIC
Former ID
DIB006460
Drug Name
ZD-7349
Synonyms
VLA-4 antagonists, Zeneca
Indication Multiple scierosis [ICD9: 340; ICD10:G35] Discontinued in Phase 1 [546708]
Company
Zeneca Group plc
Structure
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2D MOL

3D MOL
Canonical SMILES
N1(C(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(<br />=O)[C@@H](NC(=O)[C@@H]1Cc1ccccc1)CC(C)C)CC(=O)O)C(C)C)C<br />CCNC(=N)N)CCCNC(=N)N)C
CAS Number
CAS 201604-05-9
Target and Pathway
Target(s) Integrin alpha-5 Target Info Antagonist [526326]
KEGG Pathway Phagosome
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Shigellosis
Pertussis
Proteoglycans in cancer
MicroRNAs in cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy
NetPath Pathway IL6 Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway Integrin signalling pathway
Pathway Interaction Database Beta1 integrin cell surface interactions
Integrin family cell surface interactions
Arf6 trafficking events
Angiopoietin receptor Tie2-mediated signaling
CXCR4-mediated signaling events
Plexin-D1 Signaling
Syndecan-4-mediated signaling events
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Syndecan-2-mediated signaling events
VEGFR3 signaling in lymphatic endothelium
Signaling events mediated by focal adhesion kinase
Reactome Elastic fibre formation
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Integrin cell surface interactions
WikiPathways Focal Adhesion
Extracellular matrix organization
Elastic fibre formation
Arrhythmogenic Right Ventricular Cardiomyopathy
Integrin-mediated Cell Adhesion
L1CAM interactions
Integrin cell surface interactions
Cell surface interactions at the vascular wall
References
Ref 546708Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009742)
Ref 526326Eosinophil adhesion to cholinergic nerves via ICAM-1 and VCAM-1 and associated eosinophil degranulation. Am J Physiol Lung Cell Mol Physiol. 2002 Jun;282(6):L1279-88.

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