Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05JXR
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| Former ID |
DIB007635
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| Drug Name |
SC-52012
|
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| Synonyms |
N-[5-(4-Amidinophenyl)-1-oxopentyl]-L-aspartyl-L-phenylalanine
|
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| Drug Type |
Small molecular drug
|
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| Indication | Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] | Discontinued in Phase 1 | [545517] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C25H30N4O6
|
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| Canonical SMILES |
NC(=N)c1ccc(CCCCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc2cc<br />ccc2)C(=O)O)cc1
|
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| InChI |
1S/C25H30N4O6/c26-23(27)18-12-10-16(11-13-18)6-4-5-9-21(30)28-19(15-22(31)32)24(33)29-20(25(34)35)14-17-7-2-1-3-8-17/h1-3,7-8,10-13,19-20H,4-6,9,14-15H2,(H3,26,27)(H,28,30)(H,29,33)(H,31,32)(H,34,35)/t19-,20-/m0/s1
|
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| InChIKey |
VUUBSMRWDWDDPT-PMACEKPBSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Glycoprotein IIb/IIIa receptor | Target Info | Modulator | [531247] | |
| Reactome | Platelet degranulation | ||||
| Elastic fibre formation | |||||
| PECAM1 interactions | |||||
| Molecules associated with elastic fibres | |||||
| Integrin cell surface interactions | |||||
| Syndecan interactions | |||||
| ECM proteoglycans | |||||
| Integrin alphaIIb beta3 signaling | |||||
| GRB2:SOS provides linkage to MAPK signaling for Integrins | |||||
| p130Cas linkage to MAPK signaling for integrins | |||||
| VEGFA-VEGFR2 Pathway | |||||
| MAP2K and MAPK activation | |||||
| References | |||||
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