Drug Information

Drug General Information
Drug ID
D06KSV
Former ID
DIB000328
Drug Name
Omigapil
Synonyms
Omigapil); CGP-3466; CGP-3499B; Neuroprotectant, Novartis; Neuroprotectant, Santhera; Nootropic agent, Novartis; Nootropicagent, Santhera; SNT-317; TCH-346; TCH-346B
Drug Type
Small molecular drug
Indication Lateral sclerosis [ICD10:G12.2] Phase 2 [522278]
Company
Novartis AG
Structure
Download
2D MOL

3D MOL
Formula
C19H17NO
Canonical SMILES
C1(=Cc2c(Oc3c1cccc3)cccc2)CN(CC#C)C
CAS Number
CAS 181296-84-4
PubChem Compound ID
6419718
Target and Pathway
Target(s) Glyceraldehyde 3-phosphate dehydrogenase, muscle Target Info Modulator [528054]
BioCyc Pathway Superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
Gluconeogenesis
NADH repair
Glycolysis
KEGG Pathway Glycolysis / Gluconeogenesis
Metabolic pathways
Biosynthesis of antibiotics
Carbon metabolism
Biosynthesis of amino acids
HIF-1 signaling pathway
Alzheimer's disease
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TSH Signaling Pathway
PANTHER Pathway Glycolysis
Huntington disease
Pathway Interaction Database Validated targets of C-MYC transcriptional activation
PathWhiz Pathway Glycerol Phosphate Shuttle
Glycolysis
Gluconeogenesis
Mitochondrial Electron Transport Chain
Warburg Effect
Reactome Glycolysis
Gluconeogenesis
WikiPathways SIDS Susceptibility Pathways
Glycolysis and Gluconeogenesis
Alzheimers Disease
Cori Cycle
References
Ref 522278ClinicalTrials.gov (NCT00649961) Melatonin As A Novel Neuroprotectant In Preterm Infants- Dosage Study. U.S. National Institutes of Health.
Ref 528054Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3887-9. Epub 2006 Feb 27.

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