Drug Information

Drug General Information
Drug ID
D02TMO
Former ID
DIB007959
Drug Name
177Lu-AMBA
Synonyms
Ga67-AMBA; Ga68-AMBA; Galenium67-AMBA; Galenium68-AMBA; In111-AMBA; Indium-111-AMBA; Lutetium-111-AMBA; Gastrin releasing peptide receptor agonist (radiotherapeutic, cancer), Bracco; GRP-R agonist (radiotherapeutic, cancer), Bracco; 111In-AMBA; 177Lu-AMBA (cancer), Marillion Pharmaceuticals; 177Lu-DOTA-G-4-aminobenzoyl-QWAVGHLM-NH2; 67Ga-AMBA; 68Ga-AMBA
Indication Breast cancer [ICD9: 174, 175; ICD10:C50] Phase 1 [548826]
Company
Bracco SpA
Structure
Download
2D MOL

3D MOL
Target and Pathway
Target(s) Gastrin-releasing peptide receptor Target Info Agonist [531242]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCRs, Other
References
Ref 548826Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029232)
Ref 531242Multimodality imaging and preclinical evaluation of 177Lu-AMBA for human prostate tumours in a murine model. Anticancer Res. 2010 Oct;30(10):4039-48.

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