Drug General Information
Drug ID	D0H8OA
Former ID	DNCL001626
Drug Name	MK-5442
Indication	Osteoporosis [ICD9: 733.0, V07.4; ICD10:M80-M81, Z79.890]		Phase 2	[522761]
Company	Merck
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Extracellular calcium-sensing receptor	Target Info	Modulator	[531318]
Pathway Interaction Database	E-cadherin signaling in keratinocytes
Reactome	G alpha (q) signalling events
	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522761	ClinicalTrials.gov (NCT00960934) A Dose-Ranging Study of MK-5442 in Postmenopausal Women With Osteoporosis (MK-5442-001). U.S. National Institutes of Health.
Ref 531318	Antagonist for calcium-sensing receptor. JTT-305/MK-5442. Clin Calcium. 2011 Jan;21(1):89-93.

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