Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05ENJ
|
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| Former ID |
DIB009130
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| Drug Name |
Fasitibant chloride
|
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| Synonyms |
MEN-16132; Bradykinin B2 antagonist (inflammation), Menarini; MEN-11270 analogs, Menarini
|
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| Drug Type |
Small molecular drug
|
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| Indication | Osteoarthritis [ICD9: 715; ICD10:M15-M19, M47] | Phase 2 | [522981] | ||
| Company |
The Menarini Group
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C36H49Cl2N6O6S+
|
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| Canonical SMILES |
C1(CCOCC1)(NS(=O)(=O)c1ccc(c(COc2cccc3c2nc(cc3C)C)c1Cl)<br />Cl)C(=O)N1CCN(CC1)C(=O)[C@H](CCC[N+](C)(C)C)N.[Cl-]
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | B2 bradykinin receptor | Target Info | Antagonist | [531763] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cGMP-PKG signaling pathway | |||||
| Sphingolipid signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Complement and coagulation cascades | |||||
| Inflammatory mediator regulation of TRP channels | |||||
| Regulation of actin cytoskeleton | |||||
| Endocrine and other factor-regulated calcium reabsorption | |||||
| Chagas disease (American trypanosomiasis) | |||||
| Pathways in cancer | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| Pathway Interaction Database | Direct p53 effectors | ||||
| Validated transcriptional targets of deltaNp63 isoforms | |||||
| References | |||||
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