Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0H8FY
|
||||
| Former ID |
DCL000528
|
||||
| Drug Name |
Firategrast
|
||||
| Synonyms |
SB 683699; Firategrast (USAN); SB-683699; 2-[(2,6-difluorobenzoyl)amino]-3-[4-[4-(ethoxymethyl)-2,6-dimethoxy-phenyl]phenyl]propanoic Acid
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Relapsing forms of multiple sclerosis [ICD9: 340; ICD10:G35] | Phase 2 | [547712] | ||
| Company |
GSK
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C27H27F2NO6
|
||||
| Canonical SMILES |
CCOCC1=CC(=C(C(=C1)OC)C2=CC=C(C=C2)CC(C(=O)O)NC(=O)C3=C<br />(C=CC=C3F)F)OC
|
||||
| InChI |
1S/C27H27F2NO6/c1-4-36-15-17-13-22(34-2)24(23(14-17)35-3)18-10-8-16(9-11-18)12-21(27(32)33)30-26(31)25-19(28)6-5-7-20(25)29/h5-11,13-14,21H,4,12,15H2,1-3H3,(H,30,31)(H,32,33)/t21-/m0/s1
|
||||
| InChIKey |
YLFZHHDVRSYTKT-NRFANRHFSA-N
|
||||
| CAS Number |
CAS 402567-16-2
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Integrin alpha-4/beta-1 | Target Info | Modulator | ||
| KEGG Pathway | PI3K-Akt signaling pathway | ||||
| Focal adhesion | |||||
| ECM-receptor interaction | |||||
| Cell adhesion molecules (CAMs) | |||||
| Hematopoietic cell lineage | |||||
| Leukocyte transendothelial migration | |||||
| Intestinal immune network for IgA production | |||||
| Regulation of actin cytoskeleton | |||||
| Leishmaniasis | |||||
| Hypertrophic cardiomyopathy (HCM) | |||||
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | |||||
| Dilated cardiomyopathy | |||||
| Reactome | Elastic fibre formation | ||||
| Fibronectin matrix formation | |||||
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | |||||
| Cell surface interactions at the vascular wall | |||||
| Basigin interactions | |||||
| Molecules associated with elastic fibres | |||||
| Integrin cell surface interactions | |||||
| Laminin interactions | |||||
| Syndecan interactions | |||||
| ECM proteoglycans | |||||
| Other semaphorin interactions | |||||
| Localization of the PINCH-ILK-PARVIN complex to focal adhesions | |||||
| CHL1 interactions | |||||
| RHO GTPases Activate Formins | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.