Drug Information

Drug General Information
Drug ID
D0F2KX
Former ID
DIB005761
Drug Name
Granotapide
Synonyms
JTT-130
Drug Type
Small molecular drug
Indication Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] Phase 2 [522707]
Company
Japan Tobacco Inc
Structure
Download
2D MOL

3D MOL
Formula
C39H37F3N2O8
Canonical SMILES
C(C(=O)OCC)(C(=O)OCC)(c1ccccc1)COC(=O)Cc1ccc(c(c1)C(=O)<br />N(C)C)NC(=O)c1ccccc1c1ccc(cc1)C(F)(F)F
CAS Number
CAS 594842-13-4
PubChem Compound ID
11607299
Target and Pathway
Target(s) Microsomal triglyceride transfer protein, large subunit Target Info Inhibitor [531286]
KEGG Pathway Fat digestion and absorption
Reactome Chylomicron-mediated lipid transport
WikiPathways Statin Pathway
Lipid digestion, mobilization, and transport
References
Ref 522707ClinicalTrials.gov (NCT00929539) Safety and Efficacy Study of JTT-130 in Obese Type 2 Diabetic Patients. U.S. National Institutes of Health.
Ref 531286JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses food intake and gastric emptying with the elevation of plasma peptide YY and glucagon-like peptide-1 in a dietary fat-dependent manner. J Pharmacol Exp Ther. 2011 Mar;336(3):850-6.

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