Drug Information

Drug General Information
Drug ID
D0ZC0M
Former ID
DCL000380
Drug Name
GSK561679
Drug Type
Small molecular drug
Indication Alcohol use disorders; Major depressive disorder [ICD9: 303, 296.2, 296.3, 710.0; ICD10:F10.2, F32, F33, M32] Phase 2 [523144]
Company
GSK
Structure
Download
2D MOL

3D MOL
Formula
C22H26N6O2
Canonical SMILES
CCC(C1=NC(=NO1)C)NC2=CC(=NC3=C(C(=NN23)C)C4=C(C=C(C=C4)<br />OC)C)C
InChI
1S/C22H26N6O2/c1-7-18(22-24-15(5)27-30-22)25-19-11-13(3)23-21-20(14(4)26-28(19)21)17-9-8-16(29-6)10-12(17)2/h8-11,18,25H,7H2,1-6H3/t18-/m0/s1
InChIKey
VKHVAUKFLBBZFJ-SFHVURJKSA-N
PubChem Compound ID
11596613
PubChem Substance ID
16699267, 23709389, 42763447, 74597671, 123091511, 124490435, 135284359, 141717710, 141925713, 163366527, 163679248, 198987595, 226561409, 247383194, 251963078
Target and Pathway
Target(s) Corticotropin releasing factor receptor 1 Target Info Antagonist [550963]
KEGG Pathway Neuroactive ligand-receptor interaction
Long-term depression
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Cortocotropin releasing factor receptor signaling pathway
Reactome Class B/2 (Secretin family receptors)
G alpha (s) signalling events
WikiPathways GPCRs, Class B Secretin-like
Myometrial Relaxation and Contraction Pathways
Corticotropin-releasing hormone
GPCR ligand binding
GPCR downstream signaling
References
Ref 523144ClinicalTrials.gov (NCT01187511) Effects of Corticotropin-Releasing Hormone Receptor 1 (CRH1) Antagonism on Stress-Induced Craving in Alcoholic Women With High Anxiety. U.S. National Institutes of Health.
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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