Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07HLS
|
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| Former ID |
DCL000048
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| Drug Name |
Anacetrapib
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| Synonyms |
MK0859; Anacetrapib (USAN); MK-0859
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| Drug Type |
Small molecular drug
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| Company |
Merck
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| Structure |
|
Download2D MOL |
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| Formula |
C30H25F10NO3
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| InChI |
InChI=1S/C30H25F10NO3/c1-14(2)22-11-23(25(43-4)12-24(22)31)21-6-5-18(28(32,33)34)9-17(21)13-41-15(3)26(44-27(41)42)16-7-19(29(35,36)37)10-20(8-16)30(38,39)40/h5-12,14-15,26H,13H2,1-4H3/t15-,26-/m0/s1
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| InChIKey |
MZZLGJHLQGUVPN-HAWMADMCSA-N
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| CAS Number |
CAS 875446-37-0
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| PubChem Compound ID | |||||
| PubChem Substance ID |
16658560, 23677163, 42698323, 57376836, 77084272, 96025538, 125240981, 125299337, 126671698, 126731193, 134338754, 134449322, 135252031, 135723595, 135727855, 136340336, 136354914, 136367491, 136368100, 136988957, 137140669, 140430199, 144115606, 152258394, 152344255, 160647231, 162011426, 162038221, 162205119, 164023422, 164194107, 164835813, 164835814, 170499297, 174007279, 174531057, 198963790, 198991968, 203355967, 205994811, 223381545, 223435184, 223683902, 223704791, 224000756, 226842677, 242591118, 242786119, 249736586, 249821974
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| Target and Pathway | |||||
| Target(s) | Cholesteryl ester transfer protein | Target Info | Inhibitor | [537463], [537486], [537522] | |
| PANTHER Pathway | CCKR signaling map ST | ||||
| References | |||||
| Ref 536740 | Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81. | ||||
| Ref 543107 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8400). | ||||
| Ref 537463 | The end of the road for CETP inhibitors after torcetrapib? Curr Opin Cardiol. 2009 Jul;24(4):364-71. | ||||
| Ref 537486 | Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Apr;31(3):183-227. | ||||
| Ref 537522 | Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects. Br J Clin Pharmacol. 2009 May;67(5):520-6. Epub 2009 Feb 4. | ||||
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