Drug Information

Drug General Information
Drug ID
D02JMU
Former ID
DNCL002078
Drug Name
Tasquinimod
Synonyms
TASQ
Drug Type
Small molecular drug
Indication Metastatic prostate cancer [ICD9: 185; ICD10:C61] Phase 3 [523240], [542970]
Company
Active Biotech
Structure
Download
2D MOL

3D MOL
Formula
C20H17F3N2O4
InChI
InChI=1S/C20H17F3N2O4/c1-24(12-9-7-11(8-10-12)20(21,22)23)18(27)16-17(26)15-13(25(2)19(16)28)5-4-6-14(15)29-3/h4-10,26H,1-3H3
InChIKey
ONDYALNGTUAJDX-UHFFFAOYSA-N
CAS Number
CAS 254964-60-8
PubChem Compound ID
54682876
PubChem Substance ID
16502743, 39226868, 42486231, 75815233, 128833195, 135251932, 137249658, 152258245, 160647081, 160703738, 172919627, 175438432, 185998828, 198954177, 223366890, 225075769, 230401470, 249565778, 249714990, 250163182, 252451714, 252473575
Target and Pathway
Target(s) Calgranulin B Target Info Modulator [544360]
Pathway Interaction Database Endogenous TLR signaling
WikiPathways Vitamin D Receptor Pathway
IL1 and megakaryotyces in obesity
References
Ref 523240ClinicalTrials.gov (NCT01234311) A Study of Tasquinimod in Men With Metastatic Castrate Resistant Prostate Cancer. U.S. National Institutes of Health.
Ref 542970(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8098).
Ref 544360Mechanisms of action of tasquinimod on the tumour microenvironment. Cancer Chemother Pharmacol. 2014; 73(1): 1-8.

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