Drug General Information
Drug ID	D04UPW
Former ID	DIB016330
Drug Name	RWJ-68023
Synonyms	Motilin receptor antagonists, RW Johnson
Indication	Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10:A09, K58, K59.1]		Phase 1	[548041]
Company	RW Johnson Pharmaceutical Research Institute
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(N(c1cc(OCCN2CCOCC2)ccc1)CC1=C[C@](NC(=O)C(Cl)(Cl)<br />Cl)(Cc2ccccc2)CC1)Nc1ccccc1
CAS Number	CAS 223442-23-7
Target and Pathway
Target(s)	Motilin receptor	Target Info	Antagonist	[527000]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 548041	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021456)
Ref 527000	Effects of a nonpeptide motilin receptor antagonist on proximal gastric motor function. Br J Clin Pharmacol. 2004 Apr;57(4):393-401.

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