Drug Information

Drug General Information
Drug ID
D04KFR
Former ID
DIB010694
Drug Name
NVP-SAA164
Synonyms
Bradykinin B1 receptor antagonists (inflammatory pain); NVP-SAA164; Bradykinin B1 receptor antagonists (inflammatory pain), Novartis
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Investigative [541710]
Company
Novartis AG
Structure
Download
2D MOL

3D MOL
Formula
C36H45N5O5S
InChI
InChI=1S/C36H45N5O5S/c1-38-18-20-39(21-19-38)35(42)30-14-16-41(17-15-30)47(44,45)31-12-13-34(32(26-31)36(43)40-22-24-46-25-23-40)37-27-33(28-8-4-2-5-9-28)29-10-6-3-7-11-29/h2-13,26,30,33,37H,14-25,27H2,1H3
InChIKey
VODUCDWVPSEMSZ-UHFFFAOYSA-N
PubChem Compound ID
9831083
PubChem Substance ID
14790258, 24132040, 44929203, 80242950, 85226518, 103448075, 104040042, 129502844, 135650752, 137162626, 141771046, 227895645
Target and Pathway
Target(s) B1 bradykinin receptor Target Info Antagonist [541709]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Pathways in cancer
NetPath Pathway Leptin Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways Complement and Coagulation Cascades
ACE Inhibitor Pathway
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 541710(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 659).
Ref 541709(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 659).

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