Drug Information

Drug General Information
Drug ID
D05TYV
Former ID
DIB001221
Drug Name
CXCR3 antagonists
Synonyms
CXCR3 antagonists (inflammatory diseases); CXCR3 antagonists (inflammatory diseases), GlaxoSmithKline
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Investigative [552132]
Company
GlaxoSmithKline plc
Structure
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2D MOL

3D MOL
Canonical SMILES
FC(F)(c1cnc(N2[C@H](CN(S(=O)(=O)C[C@]34C(C)(C)[C@H](CC3<br />)C[C@@H]4O)CC2)C)c(c1)F)F
Target and Pathway
Target(s) C-X-C chemokine receptor type 3 Target Info Antagonist [543922]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database CXCR3-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 552132International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev. 2013 Nov 11;66(1):1-79
Ref 543922(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 70).

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