Drug Information

Drug General Information
Drug ID
D0X0ZD
Former ID
DIB008313
Drug Name
EXRD-4605
Synonyms
DIRA-7471; EXRD-4605; Epoxide hydrolase inhibitors (hypertension); Epoxide hydrolase inhibitors (hypertension), Boehringer Ingelheim
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Investigative [532153]
Company
Boehringer Ingelheim Corp
Structure
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2D MOL

3D MOL
Canonical SMILES
c1nc(ccc1n1c(cc(n1)c1cccnc1)C(F)(F)F)NC(=O)c1ccccc1
Target and Pathway
Target(s) Soluble epoxide hydrolase Target Info Inhibitor [532153]
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Peroxisome
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Metapathway biotransformation
Arachidonate Epoxygenase / Epoxide Hydrolase
Arachidonic acid metabolism
References
Ref 532153Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice. J Cardiovasc Pharmacol. 2013 Apr;61(4):291-301.
Ref 532153Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice. J Cardiovasc Pharmacol. 2013 Apr;61(4):291-301.

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