Drug Information

Drug General Information
Drug ID
D0M3AR
Former ID
DIB013801
Drug Name
L-168049
Synonyms
Glucagon antagonists (diabetes); L-168049; SCH-900822; Glucagon antagonists (diabetes), Merck & Co
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Investigative [540445]
Company
Merck Research Laboratories
Structure
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2D MOL

3D MOL
Formula
C24H20BrClN2O
InChI
InChI=1S/C24H20BrClN2O/c1-2-13-29-23-8-5-18(25)14-20(23)21-15-22(16-3-6-19(26)7-4-16)28-24(21)17-9-11-27-12-10-17/h3-12,14-15,28H,2,13H2,1H3
InChIKey
HHBOWXZOLYQFNY-UHFFFAOYSA-N
CAS Number
CAS 208188-17-4
PubChem Compound ID
5311276
PubChem Substance ID
7979919, 11056400, 15331835, 26753277, 26758783, 39340975, 74900878, 85209127, 85788190, 91746341, 103409581, 103968814, 114155724, 128059922, 135698581, 162023298, 163122843, 163688060, 178100492, 180402910, 204370403, 232093415, 241375878, 252156435
Target and Pathway
Target(s) Glucagon receptor Target Info Antagonist [543641]
KEGG Pathway Neuroactive ligand-receptor interaction
Glucagon signaling pathway
Reactome Glucagon signaling in metabolic regulation
G alpha (q) signalling events
G alpha (s) signalling events
Glucagon-type ligand receptors
WikiPathways GPCRs, Class B Secretin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 540445(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3505).
Ref 543641(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 251).

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