Drug General Information
Drug ID	D0M4HL
Former ID	DIB006066
Drug Name	P-7435
Synonyms	DGAT1 inhibitors (diabetes/metabolic disorder), Piramal Life Sciences
Indication	Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1]		Phase 1	[524180]
Company	Piramal enterprises
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c2ccc(cc2)Nc2sc3c(n2)ccc(c3)F)cc(C(=O)N[C@H](C(=O)O)<br />C(C)C)on1
Target and Pathway
Target(s)	Diglyceride acyltransferase	Target Info	Inhibitor	[549156]
BioCyc Pathway	Triacylglycerol biosynthesis
KEGG Pathway	Glycerolipid metabolism
	Retinol metabolism
	Metabolic pathways
	Fat digestion and absorption
PathWhiz Pathway	Retinol Metabolism
Reactome	Acyl chain remodeling of DAG and TAG
	Triglyceride Biosynthesis
WikiPathways	Vitamin A and Carotenoid Metabolism
	Statin Pathway
	Triacylglyceride Synthesis
	Glycerophospholipid biosynthesis
	Fatty acid, triacylglycerol, and ketone body metabolism
References
Ref 524180	ClinicalTrials.gov (NCT01764425) Clinical Trial to Study the Safety Tolerability, Pharmacokinetics, Food Effect & Pharmacodynamics of a New Compound P7435 in Healthy, Overweight and/or Obese Subjects. U.S. National Institutes of Health.
Ref 549156	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033014)

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