Drug Information

Drug General Information
Drug ID
D07NIT
Former ID
DIB007339
Drug Name
SEH inhibitors
Synonyms
SEH inhibitors (hypertension); SEH inhibitors (hypertension), Merck & Co; Soluble epoxide hydrolase inhibitors, (hypertension), Merck & Co
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Investigative [552068]
Company
Merck & Co Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
c1(c2nc(C3CCN(CC3)C(=O)NC3CC3c3ccccc3)on2)ccccn1
Target and Pathway
Target(s) Soluble epoxide hydrolase Target Info Inhibitor [532153]
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Peroxisome
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Metapathway biotransformation
Arachidonate Epoxygenase / Epoxide Hydrolase
Arachidonic acid metabolism
References
Ref 552068Soluble epoxide hydrolase inhibitors: a patent review. Expert Opin Ther Pat. 2010 Jul;20(7):941-56
Ref 532153Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice. J Cardiovasc Pharmacol. 2013 Apr;61(4):291-301.

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