Drug Information

Drug General Information
Drug ID
D0W6AQ
Former ID
DIB014076
Drug Name
TZP-201
Synonyms
JTZ-2002; IBS-D therapeutic, Tranzyme; Irritable bowel syndrome (diarrhea type) therapeutic, Tranzyme; Motilin antagonists (IBS/ fuctional dyspepsia), Tranzyme; Motilin receptor antagonists (irritable bowel syndrome/ functional dyspepsia), Tranzyme; Motilin receptor antagonists (irritable bowel syndrome/diarrhea), Tranzyme
Indication Diarrhea [ICD9: 787.91; ICD10:A09, K59.1] Investigative [543753]
Company
Tranzyme Pharma Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
FC(F)(c1cccc([C@H]2NCCOc3ccccc3CCCNC(=O)[C@@H](NC(=O)[C<br />@H](NC2=O)C(C)C)Cn2cccc2)c1)F
Target and Pathway
Target(s) Motilin receptor Target Info Antagonist [543753]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 543753(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 297).
Ref 543753(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 297).

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