Drug Information

Drug General Information
Drug ID
D0I6MZ
Former ID
DNCL002382
Drug Name
Colorectal cancer vaccine
Synonyms
GVAX (TN)
Drug Type
Vaccine
Indication Stage III colorectal cancer [ICD9: 140-229, 153, 154; ICD10:C18-C21, C20] Phase 2 [549875]
Company
BioSante Pharmaceuticals
Target and Pathway
Target(s) Granulocyte-macrophage colony-stimulating factor receptor alpha chain Target Info [543463]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
Pathways in cancer
NetPath Pathway IL3 Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database GMCSF-mediated signaling events
Alpha9 beta1 integrin signaling events
Reactome GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-3, 5 and GM-CSF signaling
RAF/MAP kinase cascade
Surfactant metabolism
Interleukin receptor SHC signaling
WikiPathways Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
References
Ref 549875Clinical pipeline report, company report or official report of Aduro BioTech.
Ref 543463(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1707).

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