TTD | Drug: D0M0OT

Drug General Information
Drug ID	D0M0OT
Former ID	DNCL002718
Drug Name	Leukemia cancer vaccine
Synonyms	GVAX (TN)
Drug Type	Vaccine
Indication	Acute myeloid leukemia; Chronic myeloid leukemia [ICD9: 205.0, 205.1, 238.7; ICD10:C92.0, C92.1, D46]		Phase 2	[524918]
Company	BioSante Pharmaceuticals
Target and Pathway
Target(s)	Granulocyte-macrophage colony-stimulating factor receptor alpha chain	Target Info		[543463]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	Hematopoietic cell lineage
	Pathways in cancer
NetPath Pathway	IL3 Signaling Pathway
NetPath Pathway	RANKL Signaling Pathway
Pathway Interaction Database	GMCSF-mediated signaling events
Pathway Interaction Database	Alpha9 beta1 integrin signaling events
Reactome	GPVI-mediated activation cascade
	G beta:gamma signalling through PI3Kgamma
	Interleukin-3, 5 and GM-CSF signaling
	RAF/MAP kinase cascade
	Surfactant metabolism
	Interleukin receptor SHC signaling
WikiPathways	Interleukin-2 signaling
WikiPathways	Interleukin-3, 5 and GM-CSF signaling
References
Ref 524918	ClinicalTrials.gov (NCT02243371) GVAX Pancreas Vaccine (With CY) and CRS-207 With or Without Nivolumab. U.S. National Institutes of Health.
Ref 543463	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1707).

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Drug Information