Drug Information

Drug General Information
Drug ID
D0U0RJ
Former ID
DNCL002766
Drug Name
Leukocyte interleukin
Synonyms
Multikine (TN)
Indication Head and neck cancer; Human immunodeficiency virus infection [ICD9: 140-149, 140-229, 279.3; ICD10:C07-C14, C32-C33, B20-B26] Phase 1 [524718]
Company
CEL-SCI
Target and Pathway
Target(s) Interleukin-2 receptor subunit beta Target Info Modulator [533675]
KEGG Pathway Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Measles
HTLV-I infection
Transcriptional misregulation in cancer
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Pathway Interaction Database IL12-mediated signaling events
SHP2 signaling
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5
Downstream signaling in na&#xef
Reactome GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-2 signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
WikiPathways IL-2 Signaling Pathway
Inflammatory Response Pathway
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
References
Ref 524718ClinicalTrials.gov (NCT02115919) Safety Study of Multikine in the Treatment of Perianal Warts. U.S. National Institutes of Health.
Ref 533675Leukocyte Interleukin, Inj. (LI) augmentation of natural killer cells and cytolytic T-lymphocytes. Immunopharmacol Immunotoxicol. 1995 May;17(2):247-64.

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