Drug Information

Drug General Information
Drug ID
D04MSX
Former ID
DNCL001634
Drug Name
Calcitonin oral
Indication Pain; Postmenopausal osteoporosis [ICD9: 338, 356.0, 356.8, 780, 733; ICD10:G64, G90.0, R52, G89, M80-M81] Phase 3 [531853]
Company
Tarsa Therapeutics
Target and Pathway
Target(s) Calcitonin receptor Target Info Modulator [544165]
KEGG Pathway Neuroactive ligand-receptor interaction
Osteoclast differentiation
NetPath Pathway RANKL Signaling Pathway
Reactome G alpha (s) signalling events
Calcitonin-like ligand receptors
WikiPathways GPCRs, Class B Secretin-like
RANKL/RANK Signaling Pathway
GPCR ligand binding
GPCR downstream signaling
References
Ref 531853A phase 3 trial of the efficacy and safety of oral recombinant calcitonin: the Oral Calcitonin in Postmenopausal Osteoporosis (ORACAL) trial. J Bone Miner Res. 2012 Aug;27(8):1821-9.
Ref 544165Transdermal Delivery of Proteins. AAPS PharmSciTech. 2011 March; 12(1): 431-441.

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