Drug Information

Drug General Information
Drug ID
D05AON
Former ID
DIB000672
Drug Name
LSI-518P
Synonyms
HDL mimetics (atherosclerosis), Lipid Sciences
Indication Cardiovascular disorder [ICD10:I00-I99] Terminated [531429]
Company
Lipid Sciences Inc
Target and Pathway
Target(s) Apolipoprotein A-I Target Info Modulator [531385]
KEGG Pathway PPAR signaling pathway
Fat digestion and absorption
Vitamin digestion and absorption
African trypanosomiasis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TNFalpha Signaling Pathway
Pathway Interaction Database FOXA2 and FOXA3 transcription factor networks
Reactome Platelet degranulation
ABC transporters in lipid homeostasis
Chylomicron-mediated lipid transport
HDL-mediated lipid transport
PPARA activates gene expression
Scavenging of heme from plasma
Scavenging by Class B Receptors
Scavenging by Class A Receptors
Retinoid metabolism and transport
Amyloid formation
WikiPathways Statin Pathway
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Human Complement System
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Binding and Uptake of Ligands by Scavenger Receptors
Visual phototransduction
Lipid digestion, mobilization, and transport
ABC-family proteins mediated transport
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 531429HDL mimetic peptide ATI-5261 forms an oligomeric assembly in solution that dissociates to monomers upon dilution. Biochemistry. 2011 May 17;50(19):4068-76.
Ref 531385Clinical review: The evolving role of HDL in the treatment of high-risk patients with cardiovascular disease. J Clin Endocrinol Metab. 2011 May;96(5):1246-57.

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