Drug General Information
Drug ID	D08UYM
Former ID	DIB012475
Drug Name	ONO-2333Ms
Synonyms	Corticotropin-releasing factor-1 antagonist (oral, anxiety/depression), Ono
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Phase 2	[522084]
Company	Ono Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Corticotropin releasing factor receptor 1	Target Info	Antagonist	[532181]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Long-term depression
NetPath Pathway	TNFalpha Signaling Pathway
PANTHER Pathway	Cortocotropin releasing factor receptor signaling pathway
Reactome	Class B/2 (Secretin family receptors)
	G alpha (s) signalling events
WikiPathways	GPCRs, Class B Secretin-like
	Myometrial Relaxation and Contraction Pathways
	Corticotropin-releasing hormone
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522084	ClinicalTrials.gov (NCT00514865) Placebo-Controlled Study of ONO-2333Ms in Patients With Recurrent Major Depressive Disorder. U.S. National Institutes of Health.
Ref 532181	Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. Drug Alcohol Depend. 2013 Mar 1;128(3):175-86.

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