TTD | Drug: D04INP

Drug General Information
Drug ID	D04INP
Former ID	DIB004920
Drug Name	Pixykine
Synonyms	Milodistim; Plasmid Immunex yeast 321; PIXY-321
Indication	Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26]		Phase 3	[521422]
Company	Immunex Corp
CAS Number	CAS 137463-76-4
Target and Pathway
Target(s)	Granulocyte-macrophage colony-stimulating factor receptor alpha chain	Target Info	Modulator
KEGG Pathway	Cytokine-cytokine receptor interaction
	Jak-STAT signaling pathway
	Hematopoietic cell lineage
	Pathways in cancer
NetPath Pathway	IL3 Signaling Pathway
NetPath Pathway	RANKL Signaling Pathway
Pathway Interaction Database	GMCSF-mediated signaling events
Pathway Interaction Database	Alpha9 beta1 integrin signaling events
Reactome	GPVI-mediated activation cascade
	G beta:gamma signalling through PI3Kgamma
	Interleukin-3, 5 and GM-CSF signaling
	RAF/MAP kinase cascade
	Surfactant metabolism
	Interleukin receptor SHC signaling
WikiPathways	Interleukin-2 signaling
WikiPathways	Interleukin-3, 5 and GM-CSF signaling
References
Ref 521422	ClinicalTrials.gov (NCT00001338) A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer. U.S. National Institutes of Health.

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Drug Information