Drug Information

Drug General Information
Drug ID
D0M9FF
Former ID
DIB002408
Drug Name
ReN-1820
Synonyms
TrkAd5; HNGF, ReNeuron; Human nerve growth factor, ReNeuron; HNGF, Enact/University of Bristol; Human nerve growth factor, Enact/University of Bristol
Indication Cystitis [ICD10:N30] Terminated [547599]
Company
University of Bristol
Target and Pathway
Target(s) Tumor necrosis factor receptor superfamily member 16 Target Info Inhibitor [544104]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Neurotrophin signaling pathway
Transcriptional misregulation in cancer
Pathway Interaction Database p75(NTR)-mediated signaling
Neurotrophic factor-mediated Trk receptor signaling
Reactome Axonal growth inhibition (RHOA activation)
NRAGE signals death through JNK
p75NTR negatively regulates cell cycle via SC1
Regulated proteolysis of p75NTR
NADE modulates death signalling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation
WikiPathways Spinal Cord Injury
BDNF signaling pathway
Signalling by NGF
References
Ref 547599Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017720)
Ref 544104Phosphorylation of Extracellular Signal-Regulated Kinases (pERK1/2) in Bladder Afferent Pathways with Cyclophosphamide (CYP)-Induced Cystitis. Neuroscience. 2009 November 10; 163(4): 1353-1362.

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