Drug Information

Drug General Information
Drug ID
D08XPN
Former ID
DIB009427
Drug Name
mab 1-7F9
Drug Type
Antibody
Indication Multiple myeloma [ICD9: 203; ICD10:C90] Phase 2 [530228], [530238]
Company
CeMines
Target and Pathway
Target(s) CD158b1 Target Info [530228], [530238], [544101]
CD158a Target Info [530228], [530238], [544101]
Killer cell immunoglobulin-like receptor 2DL3 Target Info [530228], [530238], [544101]
KEGG Pathway Antigen processing and presentation
Natural killer cell mediated cytotoxicity
Graft-versus-host diseasehsa04612:Antigen processing and presentation
Graft-versus-host disease
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellR-HSA-198933:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellR-HSA-198933:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
WikiPathways Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellWP1829:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellWP1829:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
References
Ref 530228Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood. 2009 Sep 24;114(13):2667-77.
Ref 530238Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12879-84.
Ref 530228Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood. 2009 Sep 24;114(13):2667-77.
Ref 530238Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12879-84.
Ref 544101Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood. 2009 September 24; 114(13): 2667-2677.

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