Drug Information

Drug General Information
Drug ID
D0J1FB
Former ID
DCL000382
Drug Name
GSK586529
Indication Depression; Anxiety [ICD9: 300, 311; ICD10:F30-F39, F40-F42] Phase 1 [522358]
Company
GSK
Target and Pathway
Target(s) Corticotropin releasing factor receptor 1 Target Info Antagonist [550963]
KEGG Pathway Neuroactive ligand-receptor interaction
Long-term depression
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Cortocotropin releasing factor receptor signaling pathway
Reactome Class B/2 (Secretin family receptors)
G alpha (s) signalling events
WikiPathways GPCRs, Class B Secretin-like
Myometrial Relaxation and Contraction Pathways
Corticotropin-releasing hormone
GPCR ligand binding
GPCR downstream signaling
References
Ref 522358ClinicalTrials.gov (NCT00703547) A First Time in Human Study of GSK586529 in Healthy Volunteers. U.S. National Institutes of Health.
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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