Drug General Information
Drug ID
D0G3EU
Former ID
DIB010550
Drug Name
AMG-139
Synonyms
Anti-inflammatory agent (psoriasis, IBD), Amgen
Drug Type
Antibody
Indication Crohn's disease [ICD9: 555; ICD10:K50] Phase 1 [523286]
Company
Amgen; astrazeneca
Target and Pathway
Target(s) Interleukin-23 ligand Target Info [532948]
KEGG Pathway Cytokine-cytokine receptor interaction
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Jak-STAT signaling pathway
Type I diabetes mellitus
Pertussis
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Measles
Influenza A
Herpes simplex infection
Inflammatory bowel disease (IBD)
Allograft rejection
WikiPathways Toll-like receptor signaling pathway
Aryl Hydrocarbon Receptor Pathway
Allograft Rejection
Regulation of toll-like receptor signaling pathway
References
Ref 523286ClinicalTrials.gov (NCT01258205) Multiple Ascending Doses of AMG 139 in Healthy and Crohn's Disease Subjects. U.S. National Institutes of Health.
Ref 532948Preclinical development of AMG 139, a human antibody specifically targeting IL-23. Br J Pharmacol. 2015 Jan;172(1):159-72.

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