Drug Information

Drug General Information
Drug ID
D0F7ZR
Former ID
DIB014701
Drug Name
ARX-424
Synonyms
Long-acting interferon beta (multiple sclerosis), Merck Serono/ Ambrx
Indication Multiple scierosis [ICD9: 340; ICD10:G35] Phase 1 [549740]
Company
Ambrx
Target and Pathway
Target(s) Interferon beta ligand Target Info Modulator [544317]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Osteoclast differentiation
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
Chagas disease (American trypanosomiasis)
Tuberculosis
Hepatitis C
Hepatitis B
Measles
Influenza A
Herpes simplex infection
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Reactome Oxidative Stress Induced Senescence
Interferon alpha/beta signaling
Regulation of IFNA signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Factors involved in megakaryocyte development and platelet production
WikiPathways Toll-like receptor signaling pathway
Type II interferon signaling (IFNG)
Senescence and Autophagy in Cancer
Cytokines and Inflammatory Response
EBV LMP1 signaling
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Interferon alpha/beta signaling
Regulation of toll-like receptor signaling pathway
Osteoclast Signaling
References
Ref 549740Clinical pipeline report, company report or official report of Merck Serono.
Ref 544317PEGylated interferon beta-1a in the treatment of multiple sclerosis - an update. Biologics. 2013; 7: 131-138.

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