Drug General Information
Drug ID
D0U3UJ
Former ID
DIB014665
Drug Name
CHT-25
Indication Hodgkin's lymphoma [ICD10:C81] Phase 1 [530581]
Company
University College London
Target and Pathway
Target(s) Interleukin-2 receptor alpha chain Target Info Modulator [530581]
KEGG Pathway Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Measles
HTLV-I infection
NetPath Pathway IL5 Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
TNFalpha Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Pathway Interaction Database IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Arf6 trafficking events
SHP2 signaling
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5
Calcium signaling in the CD4+ TCR pathway
Downstream signaling in na&#xef
IL12 signaling mediated by STAT4
Reactome GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-2 signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
WikiPathways IL-2 Signaling Pathway
Inflammatory Response Pathway
Interleukin-2 signaling
Allograft Rejection
TSLP Signaling Pathway
IL-7 Signaling Pathway
Interleukin-3, 5 and GM-CSF signaling
References
Ref 530581A Phase I Clinical Trial of CHT-25 a 131I-Labeled Chimeric Anti-CD25 Antibody Showing Efficacy in Patients with Refractory Lymphoma. Clin Cancer Res. 2009 Dec 15;15(24):7701-7710.
Ref 530581A Phase I Clinical Trial of CHT-25 a 131I-Labeled Chimeric Anti-CD25 Antibody Showing Efficacy in Patients with Refractory Lymphoma. Clin Cancer Res. 2009 Dec 15;15(24):7701-7710.

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