Drug Information

Drug General Information
Drug ID
D0K0WA
Former ID
DIB004441
Drug Name
CNTO-5825
Drug Type
Antibody
Indication Allergic asthma [ICD9: 493, 995.3; ICD10:J45, T78.4] Phase 1 [522965]
Company
Janssen Biotech
Target and Pathway
Target(s) Interleukin-13 Target Info [532069]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Fc epsilon RI signaling pathway
Measles
Asthma
Inflammatory bowel disease (IBD)
NetPath Pathway IL9 Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
Leptin Signaling Pathway
TSLP Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Pathway Interaction Database Glucocorticoid receptor regulatory network
IL12 signaling mediated by STAT4
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
WikiPathways SIDS Susceptibility Pathways
Cytokines and Inflammatory Response
Allograft Rejection
References
Ref 522965ClinicalTrials.gov (NCT01081691) A Study Evaluating Intravenous and Subcutaneous Administration of a Human Monoclonal Antibody (CNTO 5825) in Healthy Volunteers. U.S. National Institutes of Health.
Ref 532069Safety, tolerability and pharmacokinetics of a human anti-interleukin-13 monoclonal antibody (CNTO 5825) in an ascending single-dose first-in-human study. Br J Clin Pharmacol. 2013 May;75(5):1289-98.

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