Drug General Information
Drug ID	D00XBC
Former ID	DIB003681
Drug Name	GSK-2239633
Indication	Asthma [ICD10:J45]		Phase 1	[522973]
Company	GlaxoSmithKline plc
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	C-Cchemokine receptor type 4	Target Info	Antagonist	[543896]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Viral carcinogenesis
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
Reactome	Chemokine receptors bind chemokines
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522973	ClinicalTrials.gov (NCT01086462) Intravenous Microdose Pharmacokinetic (PK) Study With [14C]-GSK2239633. U.S. National Institutes of Health.
Ref 543896	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 61).

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