Drug Information

Drug General Information
Drug ID
D0C4BD
Former ID
DIB010022
Drug Name
KH-901
Synonyms
Comfeagen; GM-CSF gene-carrying recombinant adenovirus vaccine (solid tumor), Kanghong Biotechnologies
Drug Type
Vaccine
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [529983]
Company
Chengdu Kanghong Biotechnologies Co Ltd
Target and Pathway
Target(s) Granulocyte-macrophage colony-stimulating factor receptor alpha chain Target Info [528926]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
Pathways in cancer
NetPath Pathway IL3 Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database GMCSF-mediated signaling events
Alpha9 beta1 integrin signaling events
Reactome GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-3, 5 and GM-CSF signaling
RAF/MAP kinase cascade
Surfactant metabolism
Interleukin receptor SHC signaling
WikiPathways Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
References
Ref 529983A Phase I study of KH901, a conditionally replicating granulocyte-macrophage colony-stimulating factor: armed oncolytic adenovirus for the treatment of head and neck cancers. Cancer Biol Ther. 2009 Apr;8(8):676-82. Epub 2009 Apr 22.
Ref 528926Effects of KH901, a tumor-specific oncolytic recombinant adenovirus, on antitumor and expressing GM-CSF in xenograft tumor models. Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Jun;38(3):386-90.

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