Drug Information

Drug General Information
Drug ID
D0R9IH
Former ID
DIB015000
Drug Name
SAR-339658
Synonyms
CHR-1103; GBR-500; TMC-2003; Integrin antibody (inflammation), Chromos; Integrin antibody (inflammation), Targeted Molecules Corp; Integrin antibody (multiple sclerosis), Chromos; Integrin antibody (multiple sclerosis), Glenmark; CD49b antagonist (inflammation/multiple sclerosis), Glenmark
Drug Type
Antibody
Indication Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51] Phase 2 [524009]
Company
Targeted Molecules Corp
Target and Pathway
Target(s) Integrin alpha-2/beta-1 Target Info [543649]
Reactome Elastic fibre formation
Fibronectin matrix formation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Basigin interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
Other semaphorin interactions
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
CHL1 interactions
RHO GTPases Activate Formins
Platelet Adhesion to exposed collagen
WikiPathways TGF beta Signaling Pathway
Focal Adhesion
Human Complement System
Extracellular matrix organization
Interleukin-11 Signaling Pathway
Arrhythmogenic Right Ventricular Cardiomyopathy
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
Platelet Adhesion to exposed collagen
Integrin-mediated Cell Adhesion
L1CAM interactions
Integrin cell surface interactions
References
Ref 524009ClinicalTrials.gov (NCT01659138) Efficacy and Safety of SAR339658 in Patients With Moderate to Severe Ulcerative Colitis. U.S. National Institutes of Health.
Ref 543649(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2578).

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