Drug Information

Drug General Information
Drug ID
D04VOZ
Former ID
DNCL001744
Drug Name
TKM-ApoB
Drug Type
siRNA drug
Indication Hypercholesterolemia [ICD10:E78] Phase 4 [521850]
Company
Tekmira Pharmaceuticals
Target and Pathway
Target(s) mRNA of human apolipoprotein B Target Info [544242]
KEGG Pathway Fat digestion and absorption
Vitamin digestion and absorption
Pathway Interaction Database amb2 Integrin signaling
FOXA1 transcription factor network
Reactome LDL-mediated lipid transport
Chylomicron-mediated lipid transport
Cell surface interactions at the vascular wall
Scavenging by Class B Receptors
Scavenging by Class A Receptors
Scavenging by Class H Receptors
Platelet sensitization by LDL
Retinoid metabolism and transport
WikiPathways Statin Pathway
Binding and Uptake of Ligands by Scavenger Receptors
Visual phototransduction
Lipid digestion, mobilization, and transport
Platelet homeostasis
Cell surface interactions at the vascular wall
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 521850ClinicalTrials.gov (NCT00348686) Candesartan Effectiveness Study in Pro-B Type Natriuretic Peptides (BNP). U.S. National Institutes of Health.
Ref 544242Current Progress of siRNA/shRNA Therapeutics in Clinical Trials. Biotechnol J. 2011 September; 6(9): 1130-1146.

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