Drug Information

Drug General Information
Drug ID
D0I5QL
Former ID
DIB004198
Drug Name
CRD-5
Synonyms
Charge-regulating drugs (dyslipidemia/heart disease), Liponex
Indication Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] Discontinued in Phase 2 [548068]
Company
Liponex Inc
Target and Pathway
Target(s) Apolipoprotein A-I Target Info Stimulator [536740]
KEGG Pathway PPAR signaling pathway
Fat digestion and absorption
Vitamin digestion and absorption
African trypanosomiasis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TNFalpha Signaling Pathway
Pathway Interaction Database FOXA2 and FOXA3 transcription factor networks
Reactome Platelet degranulation
ABC transporters in lipid homeostasis
Chylomicron-mediated lipid transport
HDL-mediated lipid transport
PPARA activates gene expression
Scavenging of heme from plasma
Scavenging by Class B Receptors
Scavenging by Class A Receptors
Retinoid metabolism and transport
Amyloid formation
WikiPathways Statin Pathway
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Human Complement System
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Binding and Uptake of Ligands by Scavenger Receptors
Visual phototransduction
Lipid digestion, mobilization, and transport
ABC-family proteins mediated transport
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 548068Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021641)
Ref 536740Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81.

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