Drug General Information
Drug ID
D07JWO
Former ID
DNCL002312
Drug Name
IL-21
Synonyms
BMS-982470
Indication Colorectal cancer [ICD9: 153, 154; ICD10:C18-C21] Phase 2 [468116], [523093]
Company
Bristol-Myers Squibb
Target and Pathway
Target(s) IL-21 Target Info Modulator [550398]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Inflammatory bowel disease (IBD)
PANTHER Pathway Interleukin signaling pathway
WikiPathways Allograft Rejection
References
Ref 468116(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4987).
Ref 523093ClinicalTrials.gov (NCT01152788) Phase II Study of Interleukin-21 (rIL-21) vs Dacarbazine (DTIC) in Patients With Metastatic or Recurrent Melanoma. U.S. National Institutes of Health.
Ref 550398National Cancer Institute Drug Dictionary (drug id 409696).

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