Drug Information

Drug General Information
Drug ID
D0K3UQ
Former ID
DNCL003582
Drug Name
Vercirnon
Synonyms
1605786
Drug Type
Small molecular drug
Indication Crohn's disease [ICD9: 555; ICD10:K50] Phase 3 [523801]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C22H21ClN2O4S
Canonical SMILES
CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C=C(C=C2)Cl)C(=O)C3<br />=CC=[N+](C=C3)[O-]
InChI
1S/C22H21ClN2O4S/c1-22(2,3)16-4-7-18(8-5-16)30(28,29)24-20-9-6-17(23)14-19(20)21(26)15-10-12-25(27)13-11-15/h4-14,24H,1-3H3
InChIKey
JRWROCIMSDXGOZ-UHFFFAOYSA-N
PubChem Compound ID
10343454
PubChem Substance ID
15354919, 22707611, 33976507, 77785322, 142835702, 162109040, 163347358, 198938393, 224750702, 226677482, 246895177
Target and Pathway
Target(s) CCR9 chemokine receptor Target Info Modulator [530993]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Intestinal immune network for IgA production
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 523801ClinicalTrials.gov (NCT01536418) An Active Treatment Study to Induce Clinical Response and/or Remission With GSK1605786A in Subjects With Crohn's Disease. U.S. National Institutes of Health.
Ref 530993GSK-1605786, a selective small-molecule antagonist of the CCR9 chemokine receptor for the treatment of Crohn's disease. IDrugs. 2010 Jul;13(7):472-81.

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