Drug Information

Drug General Information
Drug ID
D0U6UK
Former ID
DNCL003506
Drug Name
Tabalumab
Synonyms
LY2127399
Drug Type
Monoclonal antibody
Indication Multiple myeloma [ICD9: 203; ICD10:C90] Phase 3 [532166], [542916]
Company
Lilly
Target and Pathway
Target(s) Tumor necrosis factor ligand superfamily member 13B Target Info Modulator [532166]
KEGG Pathway Cytokine-cytokine receptor interaction
NF-kappa B signaling pathway
Intestinal immune network for IgA production
Rheumatoid arthritis
Reactome TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
WikiPathways Spinal Cord Injury
References
Ref 532166Tabalumab, an anti-BAFF monoclonal antibody, in patients with active rheumatoid arthritis with an inadequate response to TNF inhibitors. Ann Rheum Dis. 2013 Sep 1;72(9):1461-8.
Ref 542916(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8000).
Ref 532166Tabalumab, an anti-BAFF monoclonal antibody, in patients with active rheumatoid arthritis with an inadequate response to TNF inhibitors. Ann Rheum Dis. 2013 Sep 1;72(9):1461-8.

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