Drug Information

Drug General Information
Drug ID
D0P1IS
Former ID
DCL000055
Drug Name
AS1409
Drug Type
Small molecular drug
Indication Melanoma [ICD9: 172; ICD10:C43] Phase 1 [531416]
Therapeutic Class
Anticancer Agents
Company
Antisoma
Structure
Download
2D MOL

3D MOL
Formula
C11H17NO3
Canonical SMILES
CC(C)NCC(C1=CC(=C(C=C1)O)O)O
InChI
1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3
InChIKey
JWZZKOKVBUJMES-UHFFFAOYSA-N
PubChem Compound ID
3779
PubChem Substance ID
9268, 75322, 91788, 611308, 3133594, 5272313, 8152391, 10535368, 11336069, 11361308, 11363843, 11366405, 11368967, 11371528, 11373566, 11377129, 11462280, 11467125, 11468245, 11484778, 11486793, 11488877, 11490290, 11491839, 11494763, 11534308, 14748912, 24430805, 24715029, 26512260, 26752240, 29222898, 46507323, 47216837, 47291195, 47365254, 47440329, 47515375, 47810812, 47959817, 48334566, 48416134, 49892804, 49892806, 49892807, 50104946, 50111114, 53790889, 56313305, 56313643
Target and Pathway
Target(s) Interleukin-12 ligand Target Info Modulator [551085]
KEGG Pathway Cytokine-cytokine receptor interaction
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Jak-STAT signaling pathway
Type I diabetes mellitus
Pertussis
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Measles
Influenza A
Herpes simplex infection
Inflammatory bowel disease (IBD)
Allograft rejection
WikiPathways Toll-like receptor signaling pathway
Aryl Hydrocarbon Receptor Pathway
Allograft Rejection
Regulation of toll-like receptor signaling pathway
References
Ref 531416A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma. Clin Cancer Res. 2011 Apr 1;17(7):1998-2005.
Ref 551085A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma. Clin Cancer Res. 2011 Apr 1;17(7):1998-2005.

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