Drug Information

Drug General Information
Drug ID
D04MRA
Former ID
DIB008469
Drug Name
BAY-73-7977
Synonyms
Dual-acting GLP modulator/ glucagon antagonist (diabetes), Bayer; Dual-acting glucagon-like peptide modulator/ glucagon antagonist (diabetes), Bayer
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Discontinued in Phase 1 [548274]
Company
Bayer AG
Target and Pathway
Target(s) Glucagon receptor Target Info Antagonist [550160]
KEGG Pathway Neuroactive ligand-receptor interaction
Glucagon signaling pathway
Reactome Glucagon signaling in metabolic regulation
G alpha (q) signalling events
G alpha (s) signalling events
Glucagon-type ligand receptors
WikiPathways GPCRs, Class B Secretin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 548274Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024072)
Ref 550160WO patent application no. 2012,0351,39, Prodrugs comprising an exendin linker conjugate.

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