Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00KQN
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| Former ID |
DIB010906
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| Drug Name |
PEGylated pitrakinra
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| Synonyms |
Aeroderm; Dermalast; AER-003; PEGylated pitrakinra (subcutaneous, eczema/allergy), Aerovance; PEGylated AER-001 (subcutaneous, eczema/allergy), Aerovance; PEGylated IL-4 variant (subcutaneous, eczema/allergy), Aerovance
|
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| Drug Type |
Monoclonal antibody
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| Company |
Aerovance
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| Target and Pathway | |||||
| Target(s) | Interleukin-4 | Target Info | Modulator | [889443] | |
| Interleukin-13 | Target Info | Modulator | [889443] | ||
| KEGG Pathway | Cytokine-cytokine receptor interaction | ||||
| PI3K-Akt signaling pathway | |||||
| Jak-STAT signaling pathway | |||||
| Hematopoietic cell lineage | |||||
| T cell receptor signaling pathway | |||||
| Fc epsilon RI signaling pathway | |||||
| Intestinal immune network for IgA production | |||||
| Leishmaniasis | |||||
| Measles | |||||
| Asthma | |||||
| Autoimmune thyroid disease | |||||
| Inflammatory bowel disease (IBD) | |||||
| Allograft rejectionhsa04060:Cytokine-cytokine receptor interaction | |||||
| Pathway Interaction Database | Notch signaling pathway | ||||
| IL4-mediated signaling events | |||||
| CD40/CD40L signaling | |||||
| IL12-mediated signaling events | |||||
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | |||||
| Glucocorticoid receptor regulatory network | |||||
| AP-1 transcription factor network | |||||
| IL2 signaling events mediated by STAT5 | |||||
| Calcium signaling in the CD4+ TCR pathwayreg_gr_pathway:Glucocorticoid receptor regulatory network | |||||
| IL12 signaling mediated by STAT4 | |||||
| References | |||||
| Ref 889352 | ClinicalTrials.gov (NCT00676884) A Phase 2a Study to Investigate the Effects of Repeated Administration of AeroDerm in Subjects With Atopic Eczema | ||||
| Ref 889354 | ClinicalTrials.gov (NCT00801853) A Study of the Treatment-Sparing Effects of AEROVANT?AER 001 Inhalation Powder in Asthma Patients, AEROTRIAL | ||||
| Ref 889443 | The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72. doi: 10.1038/nrd3792. | ||||
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