TTD | Drug: D0O5KH

Drug General Information
Drug ID	D0O5KH
Drug Name	Altrakincept
Drug Type	Monoclonal antibody
Indication	Asthma [ICD10:J45]		Phase 2	[889438]
Company	Novartis
Target and Pathway
Target(s)	Interleukin-4 receptor alpha chain	Target Info	Modulator	[889443]
KEGG Pathway	Cytokine-cytokine receptor interaction
	PI3K-Akt signaling pathway
	Jak-STAT signaling pathway
	Hematopoietic cell lineage
	Inflammatory bowel disease (IBD)
NetPath Pathway	IL2 Signaling Pathway
	IL4 Signaling Pathway
	EGFR1 Signaling Pathway
PANTHER Pathway	Interleukin signaling pathway
Pathway Interaction Database	p73 transcription factor network
Pathway Interaction Database	IL4-mediated signaling events
WikiPathways	Inflammatory Response Pathway
WikiPathways	IL-4 Signaling Pathway
References
Ref 889438	Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial. Am J Respir Crit Care Med. 1999 Dec;160(6):1816-23.
Ref 889443	The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72. doi: 10.1038/nrd3792.

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Drug Information