| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T29130 | ||||
| Target Name | Signal transducer and activator of transcription 3 | ||||
| Target Type | Successful |
||||
| Drug Potency against Target | Acitretin | Drug Info | Ki = 15000 nM | [552838] | |
| GNF-PF-1399 | Drug Info | IC50 = 2936 nM | [531262] | ||
| References | |||||
| Ref 552838 | Drug target identification using side-effect similarity. Science. 2008 Jul 11;321(5886):263-6. doi: 10.1126/science.1158140. | ||||
| Ref 531262 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). | ||||
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